Rosuvastatin lactone metabolism

Home Forums VisTimer Features Suggestions Rosuvastatin lactone metabolism

Viewing 1 post (of 1 total)
  • Author
    Posts
  • #20111
    chapolepin1978
    Participant


    CLICK HERE CLICK HERE CLICK HERE CLICK HERE CLICK HERE
    Oct 27, 2009 Occurrence and fate of rosuvastatin, rosuvastatin lactone, and … Fluorobenzenes
    /metabolism; Heptanoic Acids/analysis*; Heptanoic …Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult …
    Two metabolites-rosuvastatin-5S-lactone and N-desmethyl rosuvastatin-were …The metabolic clearances of the atrovastatin, simvastatin, cerivastatin, fluvastatin
    and rosuvastatin lactones were 73-, 70-, 30-, 7- and 64-fold higher, respectively …Mar 8, 2006 The major organs of metabolism and elimination include the liver and, to a …
    Although simvastatin and lovastatin are both given as lactone …P450 (CYP) metabolism of rosuvastatin appears to be minimal and is ….. tivity,
    with N-desmethyl and 5S-lactone metabolites accounting for 20 and 10%, respec
    -.May 14, 2018 Metabolism, Excretion, and Pharmacokinetics of Rosuvastatin in Healthy Adult …
    Two metabolites-rosuvastatin-5S-lactone and N-desmethyl …acid and lactone forms of several statins, including atrovastatin, simvastatin,
    cerivastatin fluvastatin, pitavastatin and rosuvastatin with respect to metabolic …Rosuvastatin (INN), marketed under the tradename Crestor, is a member of the
    drug class of …. Rosuvastatin is metabolized mainly by CYP2C9 and not
    extensively metabolized; approximately 10% is recovered as metabolite N-
    desmethyl …Rosuvastatin belongs to a class of medications called statins and is used to
    reduce plasma … Rosuvastatin clearance is not dependent on metabolism by
    cytochrome P450 3A4 to a clinically significant extent. … Rosuvastatin 5 S-
    lactone.Rosuvastatin is metabolized to a limited extent by CYP2C9 to form an N-
    desmethyl metabolite and the other metabolite is the rosuvastatin …administration of rosuvastatin [11] atorvastatin [12] simvastatin [13] lovastatin [7 …
    lactone statins are also metabolized by the CYP enzymes, except pravastatin …Jul 13, 2016 metabolic stability based on electrostatic molecular orbital studies … Lovastatin
    and simvastatin are shown in the lactone form, all … acid derivative for type 2
    statins like rosuvastatin, fluvastatin, pitastatin) which is structurally …Sep 1, 2015 on other effects, such as statin metabolism, drug-drug interac- …… rosuvastatin
    lactone, and simvastatin lactone were purchased from Toronto …J.C. Coons, P. Empey, in Drug Metabolism in Diseases, 2017 … The CPIC
    guidelines recommend a lower dose or an alternative statin (pravastatin or
    rosuvastatin) …. and possibly all statins, exist in equilibrium between the lactone
    and open …can interfere with the metabolism and disposal of the statins, thereby increasing
    risk for adverse ….. (including atorvastatin and rosuvastatin) to their lactone form.involved in oral absorption and metabolism of drugs. Additionally … Like
    atorvastatin lactone, rosuvastatin lactone is also very unstable. Stability of all the.Dec 1, 2013 Research ArticleMetabolism, Transport, and Pharmacogenomics …. in humans;
    identified metabolites include the inactive 5S-lactone, as well …5 mg: Each tablet contains 5 mg rosuvastatin (as rosuvastatin calcium). …. major
    surgery, trauma, severe metabolic, endocrine and electrolyte disorders; ….. less
    active than rosuvastatin whereas the lactone form is considered clinically inactive
    .Medscape – Hyperlipidemia, hypertriglyceridemia, hypercholesteremia-specific
    dosing for Crestor (rosuvastatin), frequency-based adverse effects, …Feb 3, 2011 isoenzyme responsible for metabolism of rosuvastatin, with CYP2C19, 2D6 and
    3A4 being involved to a … rosuvastatinlactone (inactive).

Viewing 1 post (of 1 total)
  • You must be logged in to reply to this topic.

Comments are Closed