Log p indinavir
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August 13, 2018 at 10:04 pm #15711goedowndechla1973Participant
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Indinavir is an antiretroviral drug for the treatment of HIV infection. … In vitro
studies indicate that cytochrome P-450 3A4 (CYP3A4) is the major enzyme …Indinavir | C36H47N5O4 | CID 5362440 – structure, chemical names, physical
and … 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p.Indinavir sulfate | C36H49N5O8S | CID 5462355 – structure, chemical names, …
11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 2081.It has two pKa values, 6.2 and 3.8, and the partition coefficient octanol/water (log
P) is 2.7 at pH 7. The primary degradation pathway for indinavir sulphate for …line,6 nelfinavir > saquinavir > ritonavir = lopinavir > indinavir in buffy coat cell
subsets ex …. Log P values for the PIs have been reported in the following order:
…May 1, 2003 … The terminal, log-linear period (log C versus T) was defined by the last … for the
indinavir Cmax in the every 8 h regimen (r = 0.52; P = 0.02).The average daily dose of indinavir was 2,043 mg/m<sup>2A value of P < 0.05 was considered the cutoff for significance. … The relationship
between the indinavir log-transformed AUC and parameters of immunologic …Indinavir is a protease inhibitor used as a component of highly active
antiretroviral therapy to …. Not logged in; Talk · Contributions · Create account ·
Log in …Determinação de indinavir em plasma humano e sua aplicação em estudo
farmacocinético ….. by linear regression from the points describing the
elimination phase on a log-linear plot). …. Adv. Drug Delivery Rev., v.27, n.2/3, p.
215-233, 1997.Structure, properties, spectra, suppliers and links for: Indinavir, 150378-17-9.Plasma virus load ranged from 1.6 to 5.5 log10 HIV RNA copies/mL (median, ….
SD) of cells in S + G2/M phase in cultures without IDV treatment. *, P < .05.Rory P. Remmel, Sagar P. Kawle, Dennis Weller, Courtney V. Fletcher …
Consequently, a simultaneous assay for indinavir, nelfinavir, ritonavir, and
saquinavir …Apr 15, 2006 … The inhibition of tumor growth was statistically significant from days 6 to 21 (P =
0.004 and P = 0.003, respectively). Moreover, the drug showed …Among the results, indinavir exhibited bidirectional transport across rat ileum. …..
Indinavir is a fairly lipophilic weak base as defined by a log Poctanol/water of …Previous evidence suggests that exposure to indinavir, a protease inhibitor
commonly used in antiretroviral therapy, may link to elevated HIV-SN risk. Here,
we …failure (6%) (P=0.30). Conclusions: …. period (log C versus t) was defined by
visual inspection of the last …. (P=0.54 and P=0.83 for indinavir and ritonavir AUC
,.Recently, ten cases of frozen shoulder associated with indinavir have been ….
use of indinavir (p = 0.0006) and the ritonavir-saquinavir combination (p = 0.02).Low indinavir levels, lower adherence rates for zidovudine (P = .04) and …
baseline plasma HIV RNA level (±0.8 log copies/mL), and plasma HIV RNA level
at …log P–low-PSA space can readily be rationalized via consideration ….. Indinavir.
9. 2.8. 45. 118. 0.28. 6.2. 10.2. 5.3. Lopinavir. 11. 4.7. 46. 120. 0.33. 6.3. 14.3. -
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